Journal · Formulation · 5 min
The case against synthetic fragrance in medical skincare.
Fragrance is the single most-reported cosmetic allergen. There is no clinical reason to include it in a treatment formula.
The Biomedical Emporium® formulation desk
11 May 2026
Fragrance sits at the top of the cosmetic allergen list in every published dermatology registry across the past twenty years. Its contribution to the actual efficacy of a treatment formula is nil. Its contribution to consumer preference is real, and it is why fragrance remains ubiquitous.
Biomedical Emporium formulas do not carry synthetic fragrance for that reason. A treatment cream is a therapeutic tool. It should smell like whatever the actives smell like, and no more. Anything else is a bet you make against your customer's barrier.
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